Pure Excellence Chromatography System

Detection: UV and ELSD
Pump: Flash and prep HPLC mode
System Design: Compact and fully automated

Effortless High-Performance Purification

The Pure Excellence Chromatography Systems from BUCHI Labortechnik AG deliver powerful, flexible, and safe purification solutions for demanding laboratory workflows. Designed for both flash chromatography and preparative HPLC applications, the Pure Excellence line combines advanced detection technologies, high-pressure capabilities, and intuitive software for maximum efficiency and purity.

The portfolio includes models C-905, C-910, C-915, and C-950, offering scalable solutions from advanced flash purification to integrated flash & prep HPLC systems.
 

Key features
 

✓ Advanced Detectors

• UV Detection - Broad wavelength range (200-800 nm) for precise compound identification.
• Evaporative Light Scattering Detection (ELSD) - equipped with nano-pulse technology for minimal maintenance and excellent sensitivity, ideal for compounds without chromophores.

✓ High-Performance Pumps

Triple-piston pumps - Ensure pulse-free flow, supporting:

• Up to 50 bar at 300 mL/min in flash mode
• Up to 400 bar at 150 mL/min in prep HPLC mode (C 950)

Enables efficient separation even with advanced columns and gradient methods.

✓ Flexible Gradient Capability

The system supports quaternary gradients using up to four independent solvent lines. The graphical gradient editor displays percentage gradients and time steps in an intuitive interface, making it straightforward to set up even complex multi-solvent methods — providing maximum flexibility for method development in challenging applications.

✓ Quick-Release Cartridge Holder

The innovative cartridge holder allows connection with only one hand, locking the cartridge securely in place and preventing disconnection during runs. Universal Luer connections ensure compatibility with any flash cartridge on the market, eliminating the need for adapters.

✓ Intuitive Software & Automation

• Live monitoring - observe methods and separations in real time.
• Easy gradient editing - graphical editor for quick, intuitive method creation.
• Automatic cartridge detection - an integrated QR scanner instantly recognises flash cartridges and accelerates method setup, ensuring accurate configuration with no manual input required.

✓ Flexible Sample Injection Modes

The system supports both liquid and solid loading, with manual and fully automated injection:

• Automated injection - after loading the sample into the loop, the device automatically injects after equilibration, allowing users to walk away as soon as the run starts.
• Manual injection - full operator control for specific applications.
• Clean loop option - available before or after a run without disconnecting any tubes, minimising carry-over and downtime.

✓ Enhanced Safety and Security

• Fume-Hood-free operation - Closed fraction collector and active ventilation minimize exposure to harmful vapors, allowing safe instrument use outside a fume hood.
• Error prevention technology - QR code scanning for flash cartridges and RFID reader for fraction collector racks reduce setup time and minimize user errors.
• Ingenious safety sensors - Continuous monitoring of pressure, solvent levels, and leaks ensures rapid detection of toxic vapors or overpressure, protecting samples and personnel.

Applications

Pharma R&D / APIsNatural compounds, specialty chemicals, fermentation downstream, nutraceuticals compound isolation, academia & education, post-synthesis purification